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Abstract Aerosol deep-convective cloud (DCC) interactions remain highly uncertain in the study of water cycles, energy budgets, climate projections, and air quality, partly because it is difficult to disentangle aerosol impacts from the impacts of meteorology in observational studies. Prior studies have shown that increased aerosol ingestion by DCC updrafts can influence their microphysical characteristics through the mixed-phase and condensational aerosol invigoration effects. However, other studies claim that increased aerosol loading produces different microphysical responses that are not consistent with invigoration. This study thus examines the impact of aerosol regimes on DCC microphysics by analyzing ∼1300 DCCs tracked from the Houston–Galveston WSR-88D. Fields from the fifth major global reanalysis produced by ECMWF and Modern-Era Retrospective Analysis for Research and Applications, version 2, are used to estimate meteorological and aerosol conditions near DCCs. DCC tracking was completed using the Multicell Identification and Tracking algorithm applied to radar data. Composite difference contoured frequency by altitude diagrams show statistically significant bulk differences in the vertical structure of dual-polarization radar data that are consistent with previous studies. The probabilistic differences in radar variables were typically 1%–6% above the freezing level and <4% below the freezing level. Microphysical fingerprint distributions showed that DCCs under high aerosol loading exhibit decreased warm rain, increased freezing rates, and increased vapor deposition onto ice. These signatures together are found to be consistent with increased aerosol loading leading to less warm rain, more evaporation under high tropospheric moisture conditions leading to less cold rain, and increased riming/accretion in environments with large instability leading to more cold rain.